The Temple of the Golden Pavilion. Yukio Mishima.
Hard Boiled Wonderland and the End of the World. Haruki Murakami.
Watchmen. Alan Moore.
The Illuminatus! Trilogy. Robert Anton Wilson and Robert Shea.
Nip the Buds, Shoot the Kids. Kenzaburo Oe.
The Lord of the Rings by J.R.R. Tolkien
The Garden of Eden by Ernest Hemmingway
The Sun Also Rises by Ernest Hemmingway
This Side of Paradise by F. Scott Fitzgerald
On the Road by Jack Kerouac
Dharma Bums by Jack Kerouac
Neuromancer by William Gibson
Crypto-nomicon by Neal Stephenson
Red Mars by Kim Stanley Robinson
Dune by Frank Herbert
Arcadia by Tom Stoppard
The Fannie Merrit Farmer Cook Book currently updated by Marion Cunningham
The Power of Myth by Joseph Campbell and Bill Moyers
Godel, Escher, Bach by Douglas Hofstader
Vision Science: Photons to Phenomenology by Stephen E. Palmer
Fast Food Nation by Eric Schlosser
A Green History of the World by Clive Ponting
100 Poems from the Chinese translated by Kenneth Rexroth
Hard Labor by Cesare Pavese (translated by William Arrowsmith)
[http://www.tentacle.net/~chrisr/poems/ Selected Poems]
Mountains and Rivers Without End by Gary Synder
Skinny Legs and All by Tom Robbins
East of Eden by John Steinbeck
Infinite Jest by David Foster Wallace (you'll be glad you did...eventually)
Catch-22 by Joseph Heller
Anna Karenina by Leo Tolstoy
Gone with the Wind (I had a love/hate relationship with this one)
Till I thnk of more, that's all....
Anything by Thomas Pynchon
White Noise by Don Delillo
The Satanic Verses by Salman Rushdie
Red/Green/Blue Mars by Kim Stanley Robinson (thanks Dave)
His Dark Materials trilogy by Philip Pullman (also thanks Dave)
Another Roadside Attraction by Tom Robbins
The Dice Man by Luke Rhinehart
Under the Volcano by Malcolm Lowry
Four Arguments for the Elimination of Television by Jerry Mander
On Food and Cooking by Harold McGee (non-fiction reference)
Creating a Life Together by Diana Leafe Christian (non-fiction)
If on a Winter's Night a Traveler by Italo Calvino
The Bread Baker's Apprentice by Peter Reinhart (non-fiction)
Observatory Mansions by Edward Carey
The Bone People by Keri Hulme
Perdido Street Station by China Miéville (seconded by Kevin, a hearty 'here here' by Ben)
Red Mars by Kim Stanley Robinson (I know, it is now here 3 times, but you HAVE to read it!)
The Three Californias trilogy by Kim Stanley Robinson are also good.
The Snow Queen and The Summer Queen by Joan Vinge
The Preacher graphic novels by Garth Ennis and Steve Dillon
I'm sure there is other stuff, but it is stuck in my brain. Also feel free to see DavesReadinglist.
Kevin sez: take Dave's suggestions.
Neal Stephenson says
Set this House in Order by Matt Ruff
Ilium by Dan Simmons
Iron Council by China Mieville
Perfect Circle by Sean Stewart
The I Love Bees alternate reality game
Jonathan Strange and Mr. Norrell by Susannah Clarke
The Fool's Tale by Nicole Galland (in galleys; soon to be published)
Short story collections by Etgar Keret: The Bus Driver who Wanted to be God, and The Nimrod Flip-out. Last time I checked, The Nimrod Flip-out was only available from an Australian publisher named Picador, but this should pose only the most minor of challenges to Slashdot readers. Keret is a young Israeli writer who has also done some work in film and graphic novels.
Skeletons on the Zahara by Dean King
The Lincoln-Douglas Debates and Lincoln's Cooper Union address
Battle Cry of Freedom by James McPherson
OMG...Never even seen this page before...ok...
Anything by China Miéville, Neil Gaiman, Neal Stephenson, and I've recently discovered Charles Stross.
Going back a bit, The Collected Stories of Phillip K Dick if you can stomach the mid-century political messages.